ABSTRACT
Plants contain various types of bioactive components that show many pharmacological activities. It provides instant people need and are commonly available and inexpensive. Also, medicinal plants have less side effects compared to synthetic organic chemicals. In the past decade, there has been tremendous growth in the implementation of natural products as a health regimen in Asia and European countries. Herbal natural products have a strong conceptual base and admire to be used as a drug in terms of safety and benefit for treating various diseases. Herbal medicines are becoming more popular due to its safety and efficacy during treatment. Although it contains various active chemical constituents which is useful in the management and treatment of most of diseases. Natural product mainly consists of flavonoids, tannins, saponins, fatty acids, ellagic acid, chebulic acid, alkaloids, glyco-sides, reserpine, vincristine, vinblastine, quinidine, etc. Different plants consist of different chemical constituent hence it gives different activities such as anti-ulcer, anti-microbial, anti-hypertensive, anti-diabetic, anti-cancer, anti-malarial, etc. Diabetes Mellitus is the largest chronic metabolic disorder affecting about 390 million populations across the globe and it 2is estimated to affect 592 million people by the year 2030. Many natural and semi-synthetic chalcones are important candidates that interfere with a therapeutic target such as PPAR-γ, DPP-4, α-glucosidase, PTP-1B, aldose reductase, enhances insulin production, and increase tissue sensitivity. Many organic molecules are available for the management and treatment of various types of diseases, it produces a more adverse effect than herbal medicine. Therefore, herbal medicines are more popular. Hence, major countries are contributed in the development of natural medicines.
