ABSTRACT
In spite of the development of significant elementary acquaintance regarding a variety of pathogens, the existing chemotherapy is still unacceptable as a result of imperfect effectiveness, long-term action, high cost, and unwanted side-effects. Natural products have been found to express numerous pharmacological activities. Several alcoholic, hydroalcoholic, and aqueous extracts along with phytoconstituents are reported to exhibit anti-infective effects by modulating the number of pharmacotherapeutic targets. The present chapter focuses on the therapeutic perspectives of chalcone based natural compounds in exhibiting antiviral activity against rhinovirus, human immunodeficiency virus (HIV), influenza virus, poliovirus, dengue virus, and tobacco mosaic 118virus (TMV) by modulating vital therapeutic targets like HIV-1 protease, DEN-1 NS3 protease, and neuraminidase. These natural compounds serve as interesting leads for synthetic drug fabrication by various drug design, drug discovery, and drug development approaches as well as structure-activity relationships (SARs) predictions. These compounds from nature may serve as templates for further exploration of molecular targets, structural biology, mechanism of actions (MOAs), etc.
