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      Chapter

      Proinflammatory Peptides in Relation to Other Inflammatory Mediators
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      Chapter

      Proinflammatory Peptides in Relation to Other Inflammatory Mediators

      DOI link for Proinflammatory Peptides in Relation to Other Inflammatory Mediators

      Proinflammatory Peptides in Relation to Other Inflammatory Mediators book

      Proinflammatory Peptides in Relation to Other Inflammatory Mediators

      DOI link for Proinflammatory Peptides in Relation to Other Inflammatory Mediators

      Proinflammatory Peptides in Relation to Other Inflammatory Mediators book

      ByPierangelo Geppetti, Costanza Emanueli, Michela Figini, Domenico Regoli
      BookProinflammatory and Antiinflammatory Peptides

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      Edition 1st Edition
      First Published 1998
      Imprint CRC Press
      Pages 17
      eBook ISBN 9781003064695
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      ABSTRACT

      This chapter focuses on the interactions between proinflammatory peptides and other inflammatory mediators. Some inflammatory peptides appear to act directly on effector cells, whereas other peptides preferentially act indirectly, by releasing a variety of inflammatory mediators. In describing some examples of the interactions between inflammatory peptides and other inflammatory mediators, major attention is paid to tachykinins and kinins. Mediators of inflammations include molecules that belongs to different chemical species, including amines, lipid derivatives, gases, peptides, and others. Mediators of different chemical nature may often interact, sharing a final common inflammatory pathway. Inflammatory mediators, originating from different sources and of different chemical nature, have been shown to release sensory neuropeptides from peripheral endings of capsaicin-sensitive sensory nerves. The role of prostaglandins in the activation of sensory nerves induced by kinins merits specific attention. A large variety of transmitters and mediators has been shown to prevent the release of neuropeptides from peripheral endings of primary sensory neurons.

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