Long-Acting VIP Analogs
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Long-Acting VIP Analogs book
Vasoactive intestinal peptide (VIP) is a linear and carboxy terminally amidated peptide composed of 28 amino acid residues. The particular sites of the VIP molecule which are sensitive to such cleavages or changes as a result of enzymatic or other biochemical and chemical processes are described in this section. It was suggested that these findings be utilized for further design of metabolically stable and therefore long-acting VIP analogs. In a different strategy for the development of long-acting VIP analogs, attempts were made to find out the positions of proteolytic degradation and eliminate scissile peptide bonds by replacement of the appropriate amino acid residues. Numerous analogs of VIP have been synthesized in several laboratories, either by replacement or removal of one or several amino acid residues within the sequence or by shortening or extending the molecule at the amino or carboxylic terminus.