ABSTRACT

Ceruloplasmin (CP) is the multifunctional blue [1] copper-containing plasma protein (α2-globulin), with an important role in copper transport [2], Acting as an oxidase, ceruloplasmin (EC 1.16.3.1) is involved in the regulation of the level of several phenols and aromatic amines. Also known as ferroxidase I, CP promotes the oxidation of ferrous ions (Fe2+ → Fe3+), thus preventing the accumulation of highly toxic Fe2+ ion [3], Ceruloplasmin is also a powerful plasma antioxidant and oxygen free radical (OFR) scavenger [4-7]; furthermore, ceruloplasmin is an antiinflammatory protein that acts as an acute phase serum reactant against the oxygen metabolites released by the macrophages [8].