ABSTRACT
To create safer and more selective insecticides, a comprehensive understanding of the relationships between structure and biological activity, including toxicity, is of utmost importance together with a knowledge of the biochemical mode of insecticidal action and mechanisms of toxicity. Recently, a number of quantitative procedures have been introduced into the field of structure-activity studies, among which the Hansch quantitative structure-activity relationship (QSAR) approach has been most widely and effectively used [1—3]. It assumes that the potency of a specified biological activity exerted by a series of compounds can be analyzed by an equation composed of terms of various physicochemical parameters assignable to the structures of those compounds.
