ABSTRACT
Supercritical fluid chromatography (SFC) serves as a high resolution chromatographic technique for the analysis of high molecular mass solutes that are beyond the volatility range of gas chromatography (GC). Multidimensional SFC is a relatively new technique which is growing at a rapid pace. SFC also serves as a high resolution chromatographic technique for the analysis of high molecular mass solutes that are beyond the volatility range of GC. SFC instrumentation has some similarities to both LC and GC. A syringe or reciprocating pump delivers the SFC mobile phase as a liquid to the injection valve. SFC is often applied to the analysis of high molecular mass samples such as fossil fuels, but such samples generally become more complex with increasing molecular mass because the number of possible isomers increases. In SFC, more than one of the operating parameters can be varied simultaneously; for example, the temperature may be continuously increased during a density/pressure program.
