ABSTRACT
This chapter deals with the goals associated with the application of chemometrics to bioprocesses, and the basics of new chemometric methods under study for use with sensor arrays and multichannel detectors. An important goal of the use of chemometrics in monitoring of bioprocesses is the enhancement of sensor selectivity. A second goal of the application of chemometrics is the generation of high-quality estimates of sensor precision. Chemometric methods offer an opportunity for convenient interrelation of the physical properties measured by the sensor and the properties of the bioprocess more relevant to the control algorithm. Insuring the observability of the desired bioprocess properties and the controllability of the process from the sensor measurements is a third goal of chemometrics. Chemometric techniques used to quantitate one or more species from data obtained from a multichannel sensor array or detector are classified under the term multicomponent analysis.
