ABSTRACT
This chapter investigates immediate effect of single and multiple UV treatments on susceptibility of MCA102 tumor cells to lysis by tumor necrosis factor and spleen cells. Natural cell-mediated immunity could play an important role in the elimination of tumor cells and preventing their local and metastatic growth. The efficiency of natural immunity was found also to be dependent on the level of tumor cell sensitivity to natural effector cells. The sensitivity of tumor cells to tumor necrosis factor (NK)- and tumor necrosis factor (NC) cell cytotoxicity varies in a broad range. Some tumor cells have preferential sensitivity to NK and other to NC cells. Several agents have been found to modify tumor cell sensitivity to natural cell-mediated cytotoxicity, but this effect is rather transient. In addition, same treatment could differently affect tumor cells sensitivity to NK or NC cells. UV irradiation induced some morphological changes in tumor cells. The original MCA102 and MCA105 tumor cells were strongly adherent fibroblast-like cells.
