ABSTRACT
This chapter focuses on the proposed role of oxidized Low Density Lipoprotein in atherosclerosis, the available sources of dietary antioxidants, and the mechanisms by which antioxidant nutrients can affect the process. Aerobic metabolism leads to the generation of reactive oxygen species. Interception is the main line of defense against oxidative damage and is brought about by antioxidants. In a theoretical sense, an antioxidant can be defined as “any substrate that, when present at low concentrations compared to those of an oxidizable substrate, significantly inhibits or delays oxidation of that substrate.” Also, smokers who are more prone to the atherosclerosis have lower beta-carotene levels than nonsmokers. A European multicenter trial indicated that individuals with lower adipose beta-carotene had a greater risk of myocardial infarction. Finally, the chapter discusses evidence supporting a role of dietary antioxidants in the atherosclerosis prevention.
