ABSTRACT
The most important feature of inherited mutations is that they are genetically transmitted to the next generation and, thus, can be propagated. The primary function of the Mouse Mutant Resource (MMR) at the Jackson Laboratory is to identify and characterize new spontaneous mouse mutations. The MMR is a resource of new mouse models for the entire research community. Mutations maintained in the MMR include several that have been useful for determining basic defects in various human and domestic animal diseases. The Jackson Laboratory’s MMR has three vital functions: to identify and characterize new mouse mutations for biomedical research, to propagate new and established mouse mutations in genetically defined stocks, and to distribute mice carrying these mutations to other scientists worldwide. The MMR colony is monitored routinely for quality control. The MMR contributes to progress in biomedical and basic research by providing mutant genes and animal models to research scientists.
