ABSTRACT
Numerous remutations of the ichthyosis locus have subsequently occurred, been identified, and characterized. Mutant mice may be mute with retraction of the lower lip. Abnormalities of the immune system have not been reported for this mutation. Dermal-epidermal recombination graft studies have demonstrated that the abnormal gene acts in the epidermis. Dermal-epidermal recombination graft studies have demonstrated that the abnormal gene acts in the epidermis. The ichthyosis mutation and remutations have been considered to be the “most useful of the animal models of ichthyosis for research purposes,” although the authors went on to question its value as a model for any of the human ichthyoses. The ichthyosis mutation has had limited usefulness, since it does not closely resemble a specific human disease. The ichthyosis mutation has recently been used as part of a panel of mouse mutations with skin and hair defects to investigate the role of chemical carcinogens on hair follicles.
