ABSTRACT
Satin (sa) was probably a radiation-induced mutation. It is a single autosomal recessive mutation, linked to the beige (bg) mutation, that maps to Chromosome 13. The hair of sa/sa mice has a silky appearance with a high sheen. The portion of the matrix region, the bulb, that produces the medullary cells is abnormal where they elongate in the plane of the hair axis. Ultrastructural evaluation of hair follicles revealed that medullary cells contained more fibrous material than normal. When mice carrying both beige and satin mutations were produced, the results were synergistic. The double mutation (sa bg/sa bg) has been proposed as a better model than the beige mutation for the study of NK deficiency. DNA extracts are available from the Mouse DNA Resource at the Jackson Laboratory. Embryos are preserved in the Jackson Laboratory Frozen Embryo Repository as well.
