ABSTRACT

The more widespread consideration of cell electrophoresis as an aid in biomedical research and clinical diagnostics depends on the availability of equipment capable of performing the necessary measurements on many cells quickly and accurately. During the 1970s many interesting applications of cell electrophoresis in the hematology, cardiology, and clinical immunology fields aroused increased interest in the technique. In 1990 it was concluded by Preece and Brown that a major difficulty in promoting cell electrophoresis as an advantageous technique for cellular biology was that it had to overcome the unfavorable press it had received when it was employed in the tumor test. Cell electrophoresis can be recommended for diagnosis of acute leukemia as a part of the multiparameter analysis of leukemic cells. In many cases it allows more distinct diagnosis. A further field for the application of cell electrophoresis including such histogram analysis is that concerned with investigations of blood compatibility at the level of blood-biomaterial interactions.