ABSTRACT
The synthesis of anO-linked sialoglycoprotein fragment was studied. In view of the advantages of a benzyl-based protection strategy, synthons 4, 5, 11, and 12 were designed, and coupled via a highly stereoselective glycosylation which led to 13 and 14 after manipulation of substituents. By the use of 13 and 14 as key building blocks, syntheses of glycopentapeptides havingN-terminal amino acid sequences of glycophorin AM and AN were accomplished in solution phase.
