ABSTRACT
An overview of convenient methodology and techniques used in solid phase glycopeptide synthesis by the building block approach is given. The practical details of importance in aliphaticO-linked, aromaticO-linked andN-linked glycopeptide synthesis are emphasized. The description is centred around the use of pentafluorophenyl esters as a protecting group during glycosylation and an activating group during glycopeptide assembly. Different kinds of orthogonal protection schemes are discussed dependent on the type of glycopeptide synthesized. An experimental part gives the typical procedures necessary for a successful glycopeptide assembly.
