ABSTRACT
Glycosyltransferase-mediated synthesis of unnatural oligosaccharides is reviewed, with emphasis on the use of modified sugar-nucleotide donor precursors. General considerations regarding use of the glyeosyltransferases as catalysts are discussed. Specific examples involving the use of β-(1→4)-galactosyltransferase, sialyltransferases, fucosyl-transferases andN-acetylglucosaminyltransferases are described, as well as provision of their respective donor analogues.
