ABSTRACT
The purpose of this study is to histopathologically evaluate the influence of seprafilm on postoperative adhesions. Seven adult rabbits were used for the study. The superior rectus (SR) muscle was resected and limbal conjunctival dissection was done inferonasally in both eyes. Seprafilm was inserted between the conjunctiva and SR, and under the dissected inferonasal conjunctiva of one eye. The fellow eyes served as controls. Histopathological sections were obtained on 6th postoperative week. There was no significant difference between the seprafilm inserted and control eyes with regard to inflammation, neither at the area of SR resection nor at the area of conjunctival dissection. Fibrosis was significantly less in the surgical areas where seprafilm was used as compared to the control groups. It is concluded that application of seprafilm may prove useful in strabismus surgery especially where adhesion formation may influence the outcome, and in cases where recurrent conjunctival dissection may be needed. KEY WORDS: Adhesion, seprafilm, strabismus surgery.
