ABSTRACT

Microwave irradiation is an extremely useful tool in organic synthesis and is used as an alternative source of energy to promote chemical reactions. The chapter describes some selected recent examples of microwave-assisted reactions used in the synthesis of drugs and drug-related molecules, some drug derivatives and heterocyclic compounds with promising biological applications, emphasizing the importance of the molecule and how microwaves help in the synthesis of these compounds and also the advantages shown by microwaves over conventional heating, in terms of reaction times, yield and reduction of the number of steps. Initially, theoretical aspects are described in order to understand which the microwave effect is to promote the organic reactions. Then, the chapter turns to the discussion of some of the applications of microwaves in the synthesis of medicines and heterocyclic compounds.