ABSTRACT
Carbon–carbon cross-coupling reactions are among the most important and widely applicable processes in organic chemistry and chemical industry, and Suzuki–Miyaura reactions are the most extensively used protocols for the purpose. For a decade, green chemistry and, in particular, catalysis and continuous flow have shown immense potential in achieving the goals of “greener procedures in organic synthesis”. It indeed seems difficult to conceive any chemistry in the 21st century without the industrialization of continuous flow processes in the areas of pharmaceuticals, drugs, agrochemicals, fibers, polymers, etc. A large variety of reactions employing palladium-catalyzed Suzuki–Miyaura cross-couplings have been developed under continuous flow sequences for preparing the desired biaryl derivatives. Our objective in this review is to focus on the continuous flow Suzuki–Miyaura cross-coupling reactions using homogeneous and heterogeneous catalysts.
