ABSTRACT
The design of oncolytic viruses that will efficiently and systematically attack only cancerous cells to eradicate the tumorigenic tissue is extremely challenging. Since current oncolytic viruses do not provide a robust solution for curing cancer, novel approaches for the design of such viruses are needed. We believe that one potential approach for generating better oncolytic viruses can be based on synthetic virology which relies on various types of genomic information.
Here we present and explain how combining computational biology and genomics in the design of oncolytic viruses can advance the field in a cost-effective manner.
