Recent experimental evidence revealed a thorough understanding of the involvement of functional RNA elements in the 3′ untranslated regions (UTRs) of flaviviruses with virus tropism. Comparative genomics and thermodynamic modeling allow for the prediction and functional characterization of homologous structures in phylogenetically related viruses. We provide here a comprehensive overview of evolutionarily conserved RNAs in the 3′ UTRs of mosquito-borne flaviviruses.

University of Vienna