ABSTRACT
In equivocal cases, biochemical tests may aid in the diagnosis, but these additional tests should not be used without other clinical assessments because of concerns about inaccurate interpretation. Tocolytic therapy in women with preterm prelabor rupture of membranes (PPROM) is not associated with maternal or perinatal benefits and should, in general, be avoided. History of persistent leakage of fluid and ultrasonographic diagnosis of oligohydramnios are two other confirmatory, but not diagnostic, findings. Evidence that supports a causal association between PPROM and infection is vast and includes the fact that microorganisms in the amniotic fluid are more frequently present and the rate of histologic chorioamnionitis is higher in PPROM than in intact membranes preterm delivery, and the frequency of PPROM is significantly higher in women with lower genital tract infections. Administration of broad-spectrum antibiotics is indicated, as it prolongs pregnancy and reduces maternal and neonatal infections and GA-dependent morbidity.
