ABSTRACT
This chapter presents an overview of the different types of Organic Nanocarriers (ONCs) for brain delivery, including a description of their advantages and disadvantages, and a set of preclinical studies illustrating the most effective strategies for effective brain distribution. The main difficulties in the treatment of these diseases are associated with the blood-brain barrier (BBB), a selective permeability barrier which controls the entry of systemic circulating drugs and nutrients into the brain. The benefit of local NC administration is that successful therapeutic concentrations of drugs in the brain are ensured, as well as a precise control of the concentration which is placed in the brain, guaranteeing that a drug is fully bioavailable and that any physiological obstacles to the drug, including the BBB, are prevented. Systemic administration includes all routes which involve the passage of NCs to the blood circulation, such as classical intraperitoneal injections or those through the digestive tract, lungs or transdermal administrations.
