ABSTRACT
This chapter provides an overview of the enormous possibilities offered by Hybrid Nanosystems (HNs) providing better diagnostic imaging agents, biosensors to detect specific biomarkers and enhanced targeted therapies for brain disorders. Metals as imaging agents and cytotoxic drugs have been predominantly combined for simultaneous imaging and treatment of glioma. The field of brain-related disorders has greatly benefited from HNs, paving the way towards precision medicine. The diagnosis and treatment of brain-related disorders pose a special challenge due to the presence of the blood-brain barrier and the extreme sensitivity of the brain tissue to certain molecules and drugs. Brain cancers are neoplasms located in the central nervous system characterised by high mortality and poor prognosis. Many of the studies performed to date have investigated the use of HNs constituted by an organic nanovehicle in which an inorganic compound is loaded.
