ABSTRACT
Nanoemulsions have gained enormous reputation in advanced drug delivery for their ease of formation, clarity and enhanced absorption rate leading to better bioavailability and therapeutic profiles. In spite of these advantages, nanoemulsions have a major flaw which is linked to their stability. Nanoemulsions are kinetically stable and thermodynamically unstable systems. Developing a robust nanoemulsion is of utmost importance as it ensures its safe and effective delivery in-vivo. Other important aspects of any formulation is about their biological fate. The fate of nanoemulsions within biological systems usually depends upon its physicochemical properties which include particle concentration, size, shape, electrical charge, and interfacial characteristics. The different environments of the gastro intestinal tract may cause significant changes in the physicochemical properties of nanoemulsions. This must be taken into consideration while designing an effective delivery system. The present chapter provides an insight about the fate of nanoemulsions in a biological system along with effects of the intestinal lymphatic system over the nanoemulsion carrier system.
