For the treatment of oxidative-stress related disorders, cellular uptake of dietary antioxidants is an important setback. Neurodegenerative disease such as Alzheimer’s and Parkinson disease is still an unsolved challenge. Nanotechnology can be an alternative therapeutic strategy for eradicating the problem of bioabsorption, targeted effect, and it may act as a delivery system for protecting antioxidants. This chapter is thus focused on nano-medicine-based therapy for treating oxidative stress as well as oxidative damage.