Ageing is considered as the marker for a number of neurodegenerative diseases; second most prevalent in this array is Parkinson’s disease (PD). The neuropathological characteristic of PD is dopaminergic neuronal loss and impairments in motor ability. Recently, various reports suggested the link between increased oxidative stresses and PD. The increased overload of ROS in term of upregulated oxidative stress is emerging as the key regulator in the progression of neurodegenerative conditions. Oxidative stress is generated due to the overexpression of reactive oxygen species (ROS) and nitrogen (NOS), which affects the normal brain functioning like alterations in neuron metabolism, glucose metabolism, calcium signaling, transport of neurotransmitters, and crucial mitochondrial dysfunction can obstruct the enzymatic antioxidant defense machinery, as neurons are completely dependent on the mitochondrial functioning for their high energy requirement for synaptic and neurotransmission. This makes brain predominantly susceptible toward the oxidative stress produce by the imbalance of redox potential. Therefore, the intent of this chapter is to illustrate the current considerate and management therapies used for Parkinsonism, which could be of high perspective value for translational health research. Hence, studying molecular mechanism connecting mitochondria and oxidative 240stress in the progression of PD could be helpful in exploring the new stratagem for recuperating the oxidative strategies as a promising treatment for PD.