ABSTRACT
Skin wound healing is a highly specialized and intricate mechanism for replacing damaged/injured tissues with the newer, healthy tissues. Chronic wounds, particularly burn wounds (BWs) present serious challenges to normal healing mechanisms and require specialized biomedical intensive care. Owing to its intricate pathophysiology and involvement of secondary complications (i.e., burn shock, intense wound pain, hypovolemia, immunosuppression, and severe microbial local and/or systemic infections), BW management requires a multipart therapeutic regimen order to minimize morbidity and mortality. Several conventional strategies are being used for promoting BW healing; however, the complexity of the pathophysiology of BWs demands more competitive therapies. Nanotechnology-composited wound dressings have revolutionized BWs healing and tissue regeneration because these newer modalities not only promote wound healing but also eradicate bacterial infection and prevent serious secondary complications associated with immunosuppression. Therefore, in this chapter, we have summarized and conceptualized available evidence about the therapeutic viability of biocompatible nanotherapeutics for management of mild to severe forms of BWs (i.e., first-, second-, third-, and fourth degree) with special focus on improving the therapeutic outcomes, minimizing the side effects, and improving patient compliance and quality of life.
