ABSTRACT
Nanomedicinal materials have been utilized to effectively improve various aspects of healthcare and human life, including wound healing. Diabetic wound healing can be delayed by the type of bacteria on the wound surface, non-compliance with the therapies, and poor control of blood sugar levels. In people with diabetes, wounds commonly get infected and develop into foot ulcers, often leading to limb loss. Infections caused by these pathogens require multiple treatments and a broad spectrum of antibiotics. There are promising results for nanomaterial-based treatments that are engineered with the nanoparticles and scaffolds in the nanometer range 1 to 100. The unique properties like nanoscale size, high surface area, and functionality can offer better interaction and penetration of active healing materials at the wound site. In addition, nanoparticles in suitable material combinations with therapeutic drug molecules, antibiotics, nucleic acids, growth factors, and other active biomolecules can offer regulated delivery for rapid wound healing. This chapter particularly focuses on nanoparticles (polymeric and non-polymeric), scaffolds based on natural and/or synthetic polymers, and multifunctional nanocomposite materials for diabetic wound healing and tissue regeneration as well as a brief note on recent advances and future directions for wound healing therapies.
