ABSTRACT
This chapter aims to most recent advances for the synthesis of pyrrolines by transition metal-catalyzed cyclizations. Heterocyclic ring systems are the fundamental building blocks in the majority of drugs that are used to treat animal and human diseases. Among these heterocyclic rings, those that contain nitrogen (N) are the most significant. Pyrrolines, which are the dihydro derivatives of pyrroles, have received considerable attention recently since they exhibit a large range of biological activities. An indolizine-based oligomer was synthesized by stirring of 1-(a-alkoxybenzyl)-indolizine derivative in chloroform. The oligomer was characterized as an octamer; it had been the most component within the obtained mixture of oligomers. The oligomerization was accelerated by acid and lightweight. The green color of the oligomer under acidic conditions turned raw sienna under basic conditions. A large number of indolizine derivatives were patented as effective inhibitors of 5-lipoxygenase activating protein that inhibit leukotriene production for the treatment of asthma.
