The healing of any injury requires a dynamic balance of initiation and resolution of inflammation. This review presents an overview of the various nutrients that can act as signaling agents to modify the metabolic responses essential for the optimal healing of injury-induced inflammation. Within this review, we describe a defined nutritional program consisting of an integrated interaction of a calorie-restricted anti-inflammatory diet to reduce inflammation, coupled with adequate levels of omega-3 fatty acids to enhance the resolution of residual inflammation, and followed by the intake of sufficient levels of dietary polyphenols to activate 5’-adenosine monophosphate–activated protein kinase (AMPK), which is necessary to repair tissue damaged by the initial injury-induced inflammation. The orchestration of these specific nutrients to facilitate healing is termed the resolution response. Finally, we describe the clinical markers indicative of success in the dietary optimization of the resolution response.