ABSTRACT
Synthetic amino acid-based biodegradable polymers have several obvious advantages over the naturally occurring amino acid-based polymers – proteins. These polymers have a remarkable potential to be used for constructing synthetic vaccines either via loading of epitopes in micro/nanocontainers or covalent attachment thereof to the carriers made of these polymers. In this chapter further information is given about synthetic biodegradable polymers composed of α-amino acids (AABPs), synthesis of the pseudo-proteins, and the basic properties of the pseudo-proteins, nanoparticles made of pseudo-proteins, and it concludes that the pseudo-proteins (PPs) made by step-growth polymerization of starting AA-based monomers (TDADEs) with various bis-electrophilic counter-partners have a high potential as carriers in the design of artificial vaccines – as both vehicles (nanocontainers) and water-soluble functional polymers for covalent conjugations of epitopes.
This chapter is dedicated to synthetic amino acid-based biodegradable polymers which have several obvious advantages over the naturally occurring amino acid-based polymers – proteins. These polymers have a remarkable potential to be used for constructing synthetic vaccines either via loading of epitopes in micro/nano containers or covalent attachment thereof to the carriers made of these polymers.
