ABSTRACT
Cardiovascular diseases (CVDs) are a serious threat to human health and life. There are various drugs inhibiting different mechanisms of action for the management of CVDs. These drugs have various drawbacks like drug resistance, low bioavailability, poor solubility in water, and nonspecific targeting in vivo. Nanodrug or Nanopharmaceutical delivery systems open a new era of drug delivery systems for the CVDs treatment with the advancements in the field of nanotechnology, exhibiting superiority in finding solutions for the above problems. Nonetheless, few limitations of nanopharmaceutical delivery systems (NDDSs) should be taken into consideration like cytotoxicity. Through this book chapter, different strategies using NDDSs are discussed. We have tried bringing out the future prospective of use of nanoparticles for the CVD treatment modalities.
Another important aspect is the use of nanoparticles as a diagnostic tool for CVDs. Nanotechnology is now been an integral part of the healthcare system. Imaging advancement made with nanotechnology has a massive impact in cardiology. NDDSs have potential to be exploited as theranostic approach to treat coronary artery disease, delivery of healthy cells in injured myocardium, etc. Using NDDSs, cardiovascular imaging can be further upgraded to real-time diagnosis of drastic changes during the surgery. In this chapter, keeping cardiovascular diseases as focal point, diagnostic and therapeutic approaches using the nanotechnology as tool are extensively discussed.
