Malaria is a severe disease and endemic in most countries in the world. Despite all efforts, it remains a serious public health hazard. For malaria control, effective diagnosis and treatment are importantbut inmost countries, malaria diagnosis remains a challenge. The present methodologies and approaches for malaria diagnosis are practically helpful for the laboratory technician and for the medical practitioner concerned. In comparison with traditional methods, many technologies now available provide new and additional features that can be more effective in diagnosing malaria. Almost all novel technologies for malaria identification involve nucleic acid sequences, immune chromatographic capture, and conjugated monoclonal antibodies, which provide the signs of infection. Quick recognition and prompt treatment of malarial parasite infection is the most significant aim of disease management. The importance and urgency of obtaining results rapidly from the blood samples of patients showing symptoms offer a number of sensitive approaches to the diagnosis of malaria, which are inappropriate for daily laboratory use. New technologies must be fit into the concept of successful vector control strategies, which acquire a much greater meaning today by bringing all the available technologies within a folder.