ABSTRACT
Skin wound healing is one of the urgent problems in clinical medicine at present, and effective intervention on the hemostasis, inflammation, proliferation, and remolding can promote the process of wound healing. As a unique wound dressing in skin tissue engineering, hydrogel has become a hotspot in recent decades. Hydrogel has a spatial network structure similar to the extracellular matrix (ECM), which can contain a large amount of water to create a moist environment for wounds. Similar mechanical properties can provide support for cell growth, ensure the circulation of nutrients and metabolites, promote better cell growth, and secrete various cytokines and ECM. Many natural biomaterials and synthetic polymers are used as raw materials to prepare hydrogels, achieve good hemostatic properties, cell compatibility, antibacterial properties, appropriate mechanical strength, adhesiveness and extensibility, degradability, etc. to promote wound healing and prevent scar formation. However, due to the limitations of the properties of materials and the complexity of skin structure, the ideal hydrogel has not yet been obtained, and related research needs to be further deepened.
