ABSTRACT
An overview of the possibilities for the evaluation of targeted nanoparticles for ocular drug delivery, with an emphasis on in vivo evaluation methods (animal models) is provided in this chapter. The nanosystem-based approach has led to the development of different types of nanoparticles, nanosuspensions, nanoemulsions, liposomes, nanomicelles, niosomes, nanocrystals, and dendrimers for ocular drug delivery. Low ocular drug bioavailability can occur because of the poor drug permeability through the epithelia and the fast drug elimination from the eye. Many physicochemical properties of a drug have an impact on its ocular pharmacokinetics, such as molecular weight, structure, solubility, stability, and partition coefficient. Nanoparticles have been formulated to enhance the biodistribution of encapsulated drugs. They can provide drug delivery to the target site and guide these drugs away from healthy but endangered tissues.
