ABSTRACT
Polymer-based Nanocapsules have proven to be an attractive vehicle for targeted cancer therapies, however drug encapsulation using polymeric materials has been difficult in terms of maintaining a homogeneous capsule size distribution while maintaining a small size. We employed a microfluidic system to synthesize homogenous polymeric nanoparticles (NPs) with controlled characteristics. We also demonstrated the effect of polymer concentration, flow rate ratio (FRR), and the flow rate of the aqueous phase on the NPs size. We finally simulated similar conditions to better explain the observations The optimum concentration was found to be in the range of 6 – 9 mg’ml. It was also found that higher FRR resulted in larger NPs size because of reduced mixing, and that low FRR (0.05) with high flow rates (100 μl/min) resulted in the smallest NP size
