ABSTRACT
The importance of studying aeration in industrial bioprocesses is because most of these processes are aerobic, for example, for the production of different biomolecules such as amino acids, vitamins, organic acids, antibiotics, bacteriocins, enzymes, microbial and animal cells and recombinant proteins. Mixing is the process of achieving uniformity, i.e., it is a process by which substrates are intimately dispersed throughout the reactor to afford cells that move through the reactor volume with, as far as possible, the same environment at every point. The response of the specific growth rate to dissolved oxygen concentration is analogous to other limiting substrates. In order to avoid shear stress in the cells, some systems without mechanical agitation were developed. Bubble columns systems utilize spargers in different configurations that release small diameter bubbles of gas into the liquid, from the bottom to the top of the bioreactor, promoting the mixture of the culture media and the dissolution of oxygen.
