The rise of artificial intelligence (AI) has inspired applications of new techniques and tools to support collaborative learning, with automatic data analytics and real-time adaptability features. However, little work has investigated the applications and effects of AI in computer-supported collaborative learning (CSCL) under STEM education. This chapter conducts a systematic literature review to understand the development of AI to support CSCL in STEM education from 2011 to 2021. This review examines the overall trend of AI applications designed and implemented to support CSCL and how AI supports group formation and student interactions in particular. This review further evaluates the effects of proposed AI techniques and applications in supporting group formation and student interaction. Based on review results, this chapter finally presents the design and evaluation implications and future research directions.