ABSTRACT
Metal-organic frameworks (MOFs) are a promising class of hybrid materials with defined pore aperture, tailorable composition, and structure tunable size, versatile functionality, high loading capacity, and improved biocompatibility, making them a promising candidate for the immobilization of enzymes for identification of glucose in different biological specimens. These unique properties of MOF structure are encourage to the scientist regarding its probable applicability in sensing. Sensing is one of the leading-edge approaches of recent times particularly electrochemical sensors based on metal-organic frameworks taking a worthwhile part in the detection of various chemicals, specifically in glucose sensing. Electrochemical sensors work by transforming a chemical signal into a quantifiable electrical signal and provide basic quantitative as well as qualitative information by using various analytical processes such as cyclic voltammetry (CV), differential pulse voltammetry, square wave voltammetry, chronoamperometry, linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS). Any kind of disturbance in certain glucose levels can lead to worrying complications. So, continuous monitoring and detection of blood glucose levels plays a significant role in the detection of various illnesses. MOF-based electrochemical sensors are proving to be a significant stratagem due to their short reaction time, high sensitivity, and low detection limits. Various amperometric, potentiometric, and voltammetric sensors have been developed for non-enzymatic detection of glucose, and noninvasive glucose monitoring. Moreover, MOF-based electrochemical sensors are one of the more promising approaches for glucose detection in different samples.
