ABSTRACT
In recent years, the application of MOFs in biosensors has attracted much attention due to their unique properties, such as ultra-high porosity, large specific surface area, specific adsorption, catalysis, and fluorescence or luminescence, and so on. The properties of MOF materials can be changed by changing the node metal ions and bridging ligands in MOFs, or the encapsulated functional materials in MOFs and the modified targeted substances on MOFs, thereby improving the analytical performance of biosensors constructed by MOF materials. In this chapter, the characteristics of biosensors based on MOF materials are briefly introduced, and the roles and functions of MOF materials in biosensors are also discussed. The progress of MOF-based chemical/biological sensors in the detection of biological macromolecules including antigens, antibodies, peptides, and others is reviewed. Finally, the development trend of MOF-based sensors for biological macromolecules detection has been prospected.
