ABSTRACT
The development of cost-effective, highly sensitive, and specific nucleic acids (NAs), as well as ATP biosensors, is in high demand to diagnose and treat genetic diseases and cancer cells at an earlier stage. Advancement in technology has led to the generation of unique and novel materials. Among them, metal-organic frameworks (MOFs) are the most important class of porous materials that exhibit unique properties such as large surface area, controllable structural diversity, tunable pores, and high thermal stability. Enzyme-based electrochemical detection of nucleic acids with modification of MOFs, based on organic and inorganic substrates, is a promising platform in the field of electrochemistry. In this chapter, we will give a comprehensive overview of the unique properties of MOFs, their synthetic approaches, analytical performance, targeted applications, future perspectives, and potential contribution for the electrochemical sensing of nucleic acids (DNA & RNA) and ATP.
