ABSTRACT
Metal-organic frameworks (MOFs), are highly ordered crystalline materials synthesized by the assembling of metal clusters/ions connected with organic linkers via coordination chemistry. They have attracted great attention in recent years due to their fascinating and extraordinary properties such as large surface area, porosity and cavity, high electrocatalytic activity, adsorption capacity and stability for electrochemical applications. MOFs also possess controllable and modifiable morphologies with various nanomaterials including carbon nanostructures, metal/metal oxide nanoparticles, conductive polymers, and so forth. These properties make them very attractive materials as sensing platforms for biomedical and pharmaceutical analysis. In this chapter, recent developments in the fabrication strategy of MOF-based electrochemical sensors and their analytical performances for the detection of pharmaceutical compounds are reviewed in detail. Main challenges and future potential applications of MOF-based electrochemical sensors are also discussed. This comprehensive chapter may help scientists to have creative ideas for MOF-based sensing materials for further electrochemical applications.
