ABSTRACT
The newly innovated medications have extraordinary lipophilicity and lowest water solubility (biopharmaceutics classification system class IV and II), which consequences in reduced oral bioavailability, lack of dosage proportionality, and high intra- and inter-subject variability. For a better course of therapy, solubility is the utmost commanding standard to accomplish the preferred concentration of remedy in the systemic circulation. Self-micro emulsifying drug delivery system (SMEDDS) is an exclusive technique that helps in solving problems related to the transport of medications having the lowest aqueous solubility. SMEDDS are an isotropic mixture of oils, co-surfactant, and surfactants and are highly explored in resolving the bioavailability problem of drugs having low solubility. In recent times, nutraceuticals loaded SMEDDS has attracted to the researchers of medical sciences and industries lasting to their physical constancy, simple development approaches, and can be occupied in soft gelatin capsules after solidification. On oral administration of SMEDDS, it produces a medication comprising microemulsion with a great surface area upon distribution in the gastric tract. The micro-emulsion helps in 188the transport of drugs through the gut lymphatic pathway. The present chapter deals with nutraceuticals and its categorization, therapeutic applications, flavonoids, and citrus flavonoids, SEEDS, and its classifications, mechanism of self-emulsification, the formulation components in SMEDDS, solidification techniques of SMEDDS, QbD, critical quality attributes (CQAs), risk assessment and some genuine examples related with nutraceuticals.
