ABSTRACT
Nutraceutical is a collective type of nutritional term related to pharmaceuticals. Creating a pharmaceutical commodity (tablets, powders, capsules, suppositories, etc.), which includes nutraceutical is simple for a formulator, but it is very difficult to obtain an acceptable nutraceutical bioavailability. Nutraceutical bioavailability is often poor due to a lower solubility, lower stability, and lower permeability. For all these problems related to nutraceuticals absorption, micelles can be suitably applied. Detailed discussion on the micelles is given in this section. The information includes the description of the methods for assessing essential micellar concentration, the method for preparing micelles, and various types of micelles recorded in the literature. The information includes the narrative of the critical micellar concentration determination methods, method of preparation of micelles, and diverse types of micelles which are reported in the literature. The description of the electrochemical methods for the assessment of critical micelle concentration (CMC) is given. A variety of factors affecting critical micellar concentration and the micelle size are reported. Micelles can be used for passive targeting against tumors, so various different approaches for the targeting of micelles are also described. Various examples of nutraceuticals that are loaded in different polymeric micelles showing enhanced anticancer activity in comparison to original nutraceuticals are described. Regulatory guidelines for nutraceuticals in India and in the US are described.
