ABSTRACT
In the human body, blood circulation is affected by the formation of blood clots caused by serious heart-related diseases and heart-related problems, such as acute myocardial infarction (AMI). There are many thrombolytic agents, such as streptokinase, tPa, and urokinase. Streptokinase is the most useful agent, even in underdeveloped countries, because of its low cost and easy availability. This agent is naturally synthesized by using different strains of streptococci of groups C, A, and G, and its main function is to convert plasminogen into the plasmin by activating it and to break the fibrin, which is the main cause of blood clots deposited in the veins. Streptokinase therapy is most useful in heart attacks. It has been internationally utilized in therapy, mostly in myocardial infarction, because it shows strong activity to dissolve fibrin. In the circulatory system, the inactive precursor of plasmin, also known as plasminogen, activates the plasmin. Plasminogen is activated by streptokinase by making a complex that in turn breaks the bond in plasminogen molecule giving rise to plasmin/inactive plasminogen. This is a good method for the treatment of occult pleural effusion and is a good alternative for surgical femoropopliteal procedures.
