ABSTRACT
Coriander (Coriandrum sativum) is a valuable herbal plant that has been used in traditional medicine to treat a variety of diseases. Coriander has anti-inflammatory, anti-hyperglycemic, and anti-cholesterolemic properties. This study was carried out to evaluate the effects of coriander seed extract on the liver, kidney, and testis in lead-induced Swiss albino mice observed by gross and histopathological studies. For this purpose, mice were intoxicated with 60 mg/kg b.w. dose of lead acetate for 42 days. After confirmation of intoxication, mice were divided into three groups (first, second, and third) for treatment purposes; the fourth and fifth groups were the intoxication and control groups, respectively. The first and second groups of mice were treated with vitamin E and coriander extract, respectively. The third group of mice received a combination of vitamin E and coriander seed extract. After 3 weeks of treatment, the liver, kidney, and testes were collected for the gross and histopathological studies. The gross anatomical results revealed that liver, kidney, and testes’ weight and length were significantly reduced in lead-intoxicated mice compared to the control. The gross observation revealed nodular lesions in the liver and kidneys, but no gross changes were found in the testis of lead-induced mice. Histologically, the congestion in the central vein and nodules with fibrous covering in the liver, epithelial casts in the urinary space of kidneys, an irregular arrangement of spermatogenic cells in the seminiferous tubules, and malformation of the seminiferous tubules were observed in the lead-induced mice. The liver, kidneys, and testes regained normal appearance both grossly and histo-architecturally after treatment with vitamin E, coriander seed extract, and a combination of vitamin E and coriander seed extract. Our results suggest that the coriander seed extract was more effective than vitamin E therapy in lead-intoxicated mice. Vitamin E and coriander extract are more efficient when used on lead-induced mice.
