ABSTRACT
The detection of aminoglycoside antibiotics are best realized at electrode surfaces that are virtually free of oxides, and these detections are best implemented using PAD waveforms. The interest in the analysis of the components of the fermentation broth and the determination of aminoglycoside antibiotics in biological fluids has created a need for a sensitive method of detection for these compounds. In the case of compounds without alcohol groups (e.g., penicillins, cephalosporins, and peptide-based antibiotics), only Mode II detections are often available. Koprowski, Kirchmann, and Welch showed that penicillin antibiotics can be detected by PAD following a flow injection experiment in either a direct detection mode or an indirect detection mode. For this work, eight penicillin antibiotics were tested and all showed similar electrochemical behavior at a Au electrode, implying that each undergoes a similar reaction at the electrode surface.
