ABSTRACT
Metal-organic frameworks (MOFs) have gained a lot of attention in past few decades for biomedical applications. They are considered to be a promising form of nanocarrier for drug delivery due to their well-distinct structure, high porosity, tunable pore size, high surface area, and ease of surface functionalization. The properties, such as high drug-loading capability and incredible biocompatibility, make it an excellent candidates in tumor therapy. The targeting method can improve efficacy by increasing drug concentration at the tumor site; on the other hand, it can improve safety by preventing drug release in healthy tissues. In this chapter, we discussed most recent advances in MOFs as drug delivery carriers for tumor therapy, diagnosis, or both (theranostics). Furthermore, various techniques and strategies included in synthesizing MOFs with different drug release mechanisms under different stimuli, such as pH, temperature, redox, magnetic field, enzyme, and light, were summarized and discussed.
